Funniest Role: Beth in Wet Hot American Summer (2001)
Memorable Quote: "I guess I just prefer to see the dark side of things. The glass is always half-empty. And cracked. And I just cut my lip on it. And chipped a tooth."

Janeane Garafalo, our favorite dysfunctional camp counselor in Wet Hot American Summer, is unconventionally hot. Though we wouldn't categorize her as an unequivocal knockout, her quick wit and unique sense of humor is more than enough to steal our love and affection. After flipping her career from a virtually unknown stand-up comedian in the '80s to becoming a critically acclaimed personality on The Larry Sanders Show and SNL by the mid-'90s, it was clear she had more star power than your average celeb. And she hasn't eased off the gas since. One look at her long list of accomplishments and you'll be thirsty to put a ring on it.