Series: The Mindy Project

Premiere Date: September 25 on Fox

Where You've Seen Her: Gossip Girl (31 episodes), One Life to Live (103 episodes)

Amanda's a stunning beauty, but she won't be able to carry this sitcom—that's up to star Mindy Kaling, ex-The Office star, who plays the young ob-gyn Amanda's character Shauna is a receptionist for. Amanda plus endless opportunities for vagina jokes? Now that's a show worth watching.