6. Futura

Maybe more than anyone on this list, Futura's career speaks for itself. Four decades in, and he is still at it. In 2012, we witnessed one of his biggest ventures yet, a collaboration with Hennessy that placed his design on 360,000 bottle labels to be sold around the world. Read more about his work this year in our in-depth online cover story, Futura: The Art of Reinvention.