Location: Buenos Aires, Argentina
Notable Businesses: Sabater Hermanos, DesiderataSoldBA, Boutique del Libro, Bolivia

Named after its similarity to the New York neighborhood, Palermo SoHo is perfect for dining, drinking, and shopping. If that gets old, there are plenty of art galleries, such as Hollywood in Cambodia which features street art and a sick, graffiti-decorated downstairs bar called Post Bar. Ir de Compras is your destination for shopping—you'll find all the usual chains, plus a plethora of boutique clothing stores. Enjoy coffee and light lunches at Wi-Fi hotspots like Mark’s Deli & Coffee House and Boutique del Libro, or get a full meal at La Cabrera or La Fabrica del Taco, which (some say) is the best Mexican restaurant in all of Buenos Aires.