Game: South Carolina vs. Tennessee
Injury: Dislocated right knee
Former South Caroline running back Marcus Lattimore was a supremely talented college football player who—for one reason or another—could never seem to have that breakout Heisman campaign that so many people expected him to have. This freak injury, which he sustained during his junior year, was one of the factors that played in to that disappointment. As you can see, Lattimore gets caught up in a pile, and his leg just does some things that legs are not supposed to do. Despite the fact that he would never play a down of college ball after this, Lattimore declared for the draft anyway, getting picked up by the San Francisco 49ers in the fourth round of the 2013 draft.