Record: 10 - 1
Finish: Conference Champions
Coach: Charley Moran
Best Player: Bo McMillin

How does a 6-0 game between a tiny Liberal Arts school in Kentucky and Harvard become one of the most memorable games of all time? When the game represents one of the greatest upsets in sports history. Centre visited the Crimson a year after Harvard won the second of two consecutive National Championships. The Praying Colonels had challenged the Ivy Leaguers in 1920 only to come up short in the second half. But in '21 Centre shocked Harvard en route to a 10-1 season, outscoring their opponents 314 to 6. The 6 points being Harvard's.