FSU @ Clemson (Saturday, 3:30 p.m., ESPN)

Spread: Clemson (-2.5)

This game poses the biggest question mark of all the big games this weekend, mainly because half of Florida State’s team is either questionable or out, including their quartback EJ Manuel. If Manuel plays, this game will be more closely contested; however, he is missing a few weapons on the offensive side of the ball, not to mention that returner/cornerback Greg Reid is mostly likely out as well. I like how Clemson looked last week, even though I picked against them. When they're in Death Valley, they’re a very tough team to beat. Clemson uses many formations mixed in with a ton of personnel to confuse the defense, and it always helps to have one of the fastest freshman in the country: Sammy Watkins.

Even if Manuel does play Clemson will still win and cover.