Network: NBC
Air Dates: September 21, 1998–May 18, 2006
Stars: Debra Messing, Eric McCormack, Megan Mullally, Sean Hayes

We don't want to get too political about this but Will and Grace has educated more people about homosexuality than most schools. A lot of people said the now-classic sitcom was doomed to fail, because who wants to watch two main characters who have no chance in being sexually attracted to each other? Uh, lots of people, because it's hilarious.

Will and Grace was groundbreaking; it was the first TV show to have openly gay main characters. Plus, it had different kinds of soul mates. Like flamboyantly and fabulously gay Jack (Hayes) and the borderline-alcoholic sass-machine, Karen (Mullaly). —TA