Played by: Rose McGowan

Man, we love Scream. Slasher film mixed with tongue-in-cheek comedy? Brilliant. Of course, when we watched in the '90s is was more horrifying than it was hilarious. Still, there was one source of comfort in the form of the best-friend character Tatum, played by the gorgeous Rose McGowan. She's the perfect combo of spunky, cute, and cynical.