Boss: Tyrant (Second Encounter)
Game: Resident Evil: Code Veronica X
How To Beat Him/her: Granted, all Tyrants are difficult to beat, but this one...wow. He was resilient, and the fact that you didn't have much space to work with, didn't help either.
In order to successfully defeat Tyrant, there's two options: unload on him with 25 explosive arrows, or a combination of explosive arrows and B.O.W. gas rounds. If you decide to take the latter, three gas rounds and six explosive arrows should do the job. After that, catapult the crate at Tyrant and watch him explode. Anyone for barbecued Tyrant? No? Oh, ok.