Episode: "You Got F'd in the A" (s8e4)
Original Air Date: April 7, 2004

Long before the mind-bending spacecapades of Isaac Clarke in Dead Space, there was South Park's foreshadowing, Space Brain Damage. More likely it was built on the shoulders of space shooter classics like Galaga and R-Type, maybe even Metroid, elucidating the appeal of the universal void. Space is eerie enough without mental incapacitation.