Character: Spider-Man
Game: Every Spider-Man title (1982-present)

At this point, Spider-Man has made appearances on more than 15 platforms over the course of 30 years. The guy's got more staying power than the clap. That might have something to do with the "everyman" relatability of Peter Parker. More likely, it's his superhuman strength, speed, agility, spider-sense, and web-slinging that have given him his stayin power.