Game: Serious Sam (2001)

First person shooter fans have cried out for this boss' rightful place in gaming history. He tears through pyramids. He launches rockets and balls of lava and towers over you at 300 feet. Ugh Zan III can regenerate health and send minions towards you to whittle down your defenses. Besides being a Great Admiral in the alien horde, Zan takes three stages to fight. The goliath is considered by many gamers as one of the greatest bosses of all time.