'Half-Life 2' (2006-2007)

Alyx Vance is still one of the best female characters in games, more than half a decade after the debut of Half-Life 2. And that's because she bucks basically every stereotype there is: she's no damsel, for one thing, and she's one of the least sexualized females in games. Unless you use one of those mods that makes her boobs huge and gives her a ton of makeup, in which case fuck you.