Game: Fight Night Round 4

Muhammad Ali on G.O.A.T. difficulty is the closest thing modern gamers will get to matching gloves with the infamous Tyson from Mike Tyson's Punch-Out!! Ali's speed was unmatched and his defense prevented you from ever landing a clean shot, also his stamina...good lord his stamina! Ali represented what may well be the final epic match up in boxing video games because in five years this sport will probably no longer exist.