When: 2000-2001

After nine years of marriage, Meg Ryan and Dennis Quaid looked like they would be one of the few Hollywood couples that could overcome the obstacles and stand the test of time. However, after Meg met Russell Crowe on the set of 2000's Proof of Life, that proved not to be the case. Soon after hooking up with the New Zealand actor on set, Meg and Dennis announced their divorce. In later years, Ryan alleged that the split wasn't all her fault. The adorable actress claimed that Quaid was unfaithful during their marriage as well.