Funniest Role: Nancy Botwin on Weeds
Memorable Quote: "I was devastated when I found out that my boyfriend was leaving me for another woman, I was seven months pregnant, for crying out loud! I was also devastated when I ran out of chocolate milk, things pass, life goes on."

It hasn't always been dime bags and drug deals for Mary-Louise Parker. She paid her dues in the acting game during the '80s and '90s, building a strong career in theater while bouncing between minor movie roles. Her official arrival to the Hollywood came after award-winning roles in The West Wing and Angels in America. Shortly thereafter, Parker took on the role as Nancy Botwin in the popular Showtime series Weeds, where she has not only carried the show through seven successful seasons, but has done so with witty charm and next level sex appeal.