Funniest Role: Host of Chelsea Lately
Memorable Quote: "My tendency to make up stories and lie compulsively for the sake of my own amusement takes up a good portion of my day and provides me with a peace of mind not easily attainable in this economic climate."

Say what you want about Chelsea Handler, but you can't front like she's not the least bit hilarious. The 37-year-old funny girl doesn't pull any punches and anyone, including celebrities, can fall victim to her candid and oftentimes offensive humor. It's all in good fun, though, as Handler knows she can end up on the butt end of jokes because of her history of extracurricular exploits (DUI arrests, illicit drug use, and a rather indiscriminate sexual appetite). But that's what makes Chelsea likable: She's not one hide the fact that she's had a few missteps in her journey to superstardom.