Penny and Leonard are the poster children for a couple so out of each other’s leagues that they’re hardly playing the same game. The plot of the show is  straightforward: a group of geeks luck out with a hot neighbor, Penny, played by Kaley Cuoco.

The least geeky of the bunch, Leonard (Johnny Galecki), is immediately, and understandably, infatuated with her. Penny is attracted to Leonard presumably because he’s different than all of the other muscle-men Hollywood types that she’s dated before. Totally stable foundation for a relationship? In series creator Chuck Lorre’s world, yes. But hey, that guy also cast Charlie Sheen in Two and a Half Men.