Parasite Eve is a classic PlayStation title with one of the weirdest plots we've ever experienced. Suffice to say it involves an opera-singing animorph named Eve who causes onlookers to spontaneously combust by manipulating their cells' mitochondria.

It's also the only game we've ever played in which Central Park gets covered in the lovely goo that results from a crowd of people being abruptly turned inside-out on a cellular level.