Sweet Tooth, one of the best creator owned non-superhero comics currently available, will be ending its run this December in issue #40 of the series, according to the Vertigo Blog. In the blog, Sweet Tooth creator Jeff Lemire explained the rationale behind the decision to end the cult-favorite series:

So why end it now? I want to make one thing really clear…Sweet Tooth is not being cancelled. The decision to end it at #40 is entirely my choice. Truth is, I always knew what the ending of Sweet Tooth would be. It was one of the first ideas I came up with when writing the pitch for the book. The beginning and the end of this story were always pretty much written in stone, it was the middle bit that was fluid, and grew and changed as I went along. So, for me it’s incredibly gratifying to finally get to the end of the journey with Gus and Jepperd. Everything I’ve done with the series so far, everything I’ve built month after month, has all been about this, the final story.

The series will begin its last story arc, titled "The Wild Kingdom," in issue #36, which will lead to the fully-painted finale in #40. If you haven't started reading Sweet Tooth yet, we suggest you pick up the back issues and trade paperbacks immediately. You can thank us later. 

[via Vertigo Blog