1. Fawkes 

Game Appearances: Fallout 3

Original Gender: Female

With his rippling muscles, deep voice, and affinity for going topless most assumed that the lovable supermutant was a guy. Talking to the Chief Physician while studying the FEV virus that transformed Fawkes from human to colossus we learn that the subject in Fawke's cell was originally a female. Though the experiment rendered Fawkes completely asexual, it was a physical transformation that would give Buck Angel a run for his money.