System Shock

Old school but she still makes the cut. System Shock may have been released back in 1994 but SHODAN (Sentient Hyper-Optimized Data Access Network) endures as a memorable she-villain all the same. A vast AI network tasked with the day to day operations of running a deep space mining station, players accidentally set her free to systematically slaughter, mutate or cybernetically augment all humans on the station. A condescending, cold blooded, single purposed computer that insults players as "insects" and "pathetic creatures of meat and bone". Yowza! When are we humans ever going to learn to never trust machines? I turn my back to my microwave when I'm counting the money in my wallet.