Seth Green as Joker

You know him as: Chris Griffin (Family Guy), Oz (Buffy), Scott Evil (Austin Powers), creator and producer (Robot Chicken)

Seth Green is a bonafide nerd himself, and his status as the creator of Robot Chicken and the voice of Chris Griffin only reaffirm that. As Joker, he's provided the comic relief in more than a few dire moments on the Normandy. He's also shown us that human-on-cyborg love is not only possible; it's downright beautiful! His relationship with EDI was one of the highlights of Mass Effect 3 for us (their couple name is Eder, or Jokdi, or something). Now if only he could actually get with Tricia Helfer…