Professor Layton vs. Phoenix Wright
Alright, so Professor Layton vs. Phoenix Wright hasn't even been released yet, and we'll likely never see it in the US anyway. But this gets a spot on the list for the sheer awesomeness of its concept. And what else but awesomeness could occur when gaming's greatest detective and spikiest lawyer meet face to face?
We're guessing the two eccentrics will rub each other the wrong way for a while before joining forces to form the ultimate criminal-catching-and-defense duo. It's slated to hit the 3DS this year, and while it seems unlikely so far, we've still got our fingers crossed for a US version.