Marvel vs. Capcom
Way to be the biggest whores in the industry, Capcom. You're worse than the casts of Dead or Alive Xtreme Beach Volleyball and Rumble Roses XX combined (speaking of which, what a mash-up that would be). That said, Capcom, we totally fucking love you for it.
No other mash-up franchise gets gamers' panties in a bunch quite like Marvel vs. Capcom, with the latest, Ultimate Marvel vs. Capcom 3, dominating fighting games in 2011. The only game on the horizon we can see taking its crown is Street Fighter x Tekken, but then, we'll have to play it to know for sure. In the meantime, we're going to keep this grudge match between Spider-Man and Ryu going until the end of time.