Louis C.K. On Louie (2010-Present)
On Louie, show-running comedian Louis C.K. portrays a newly divorced father attempting to raise his two daughters in New York City and balance family responsibilities with his career as a comedian. The show is loosely based on C.K.'s own life, but pumped up with extra awkward hilarity, such as his character's obsessive crush on a platonic mommy friend Pamela (played by his real-life comedian friend Pamela Adlon).
Verdict: In every good joke there is a kernel of truth. Plus, C.K. writes it all himself, so you do the math.