Téa Leoni On The X-Files (2000)
Téa Leoni's role in The X-Files was a pretty small one, but significant all the same: Leoni plays herself starring in a film based off of a case Mulder (David Duchovny) and Scully (Gillian Anderson) investigated. She's mostly seen playing Scully in the fake movie on screen in a theater, but when she does interact with Mulder and Scully, there's a pretty meta joke about her having a crush on Mulder. Leoni was, of course, married to Duchovny at the time of filming.
Verdict: Well, she was married to David Duchovny, so it's safe to safe she was into him.