When: December 2010
Comment: "[Angelina Jolie] is a homewrecker, she is. She can rescue as many babies from as many countries as she wants to. I don't fucking believe you. She gives interviews, 'I don't have a lot of female friends.' Because you're a fucking c*nt. You're a fucking bitch!"

Chelsea Handler's and Jennifer Aniston's close friendship isn't a secret. The two even vacationed in Mexico together. Apparently, the overprotective friend in Handler simply came out at one of her comedy shows.