Gears of War series
The Lancer almost lost the top spot to the Portal gun, until we remembered that it's a combination of a chainsaw and an assault rifle. Epic really struck gold with this one, and the Gears series has become one of the biggest franchises in the industry. That satisfying squelch as the saw blade rips into Locust and human alike is one of the coolest sound effects ever. And real life Lancers like the one above make us salivate, even though we'd probably only cut trees with them, too, just like Cliffy (we're pacifists at heart).
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