4. ASTRO BOY (Fuji TV, 1963-1966)
Originally airing in Japan and later imported over to the States, Astro Boy is one of the most significant cartoons of all time because it introduced countless Americans to manga and anime. The story focuses on an incredibly powerful robot named Astro Boy, which was created in a futuristic world where robots have assimilated themselves into society.
Astro Boy was modeled after the late son of his creator, Doctor Tenma, and his adventures usually placed him at odds against humans, aliens, and even other robots. There have been various remakes of the original cartoon, and even a CGI film in recent years, but none of those adaptations come close to matching the charm and whimsy of the original black and white cartoon.