25. Shelley Long as DeDe Pritchett on Modern Family
In case you were wondering what drove Jay Pritchett (Ed O'Neill) into the loving arms of the younger, sultry Gloria (Sofia Vergara) besides the obvious, look no further than the episode which features guest star Shelly Long as his ex-wife, DeDe. Simply put, she's a nutjob, and despite her marriage to Jay ending on natural terms, she can't help but jealously put hands on Gloria every time they're in the same room, even after causing a scene to end all outbursts at the couple's wedding.
She also continues to screw with their two children, like the time she showed up with daughther Claire's (Julie Bowen) high-school boyfriend on her arm. We can't wait to see what stunt she pulls during her next appearance.