24. Mission Hill (1999-2000, The WB; 2002, Adult Swim)
From two of the best writers to ever work on The Simpsons, Bill Oakley and Josh Weinstein, Mission Hill was an animated look at the life of aspiring cartoonist, and professional slacker, Andy French. During its brief time on the air, the series never provided audiences with the laugh-out-loud humor that perhaps some were expecting, yet it was incredibly sharp and witty without having to stoop to typical cartoon shenanigans.
Unfortunately, the WB Network had little faith in the show, so there was very little marketing behind it and episodes aired sporadically. In the end, Mission Hill never quite gained a large enough audience to warrant a second season, but for a brief time it was actually a welcome addition to the animated sitcom genre.