Everyone knows that actresses brave enough to physically overhaul their image have a better chance at scoring trophies, hence the fact that Meryl Streep, Michelle Williams, Glenn Close and Rooney Mara are all in the running for Best Actress at next year's Golden Globes. Rather than playing into the glam of "the Hollywood actress," these thesps choose to take their memorable career performances to entirely new and refreshingly unexpected levels, most of them at the risk of their own health and sanity. See how far some actresses are willing to go and check out The 15 Most Drastic Movie Role Transformations.