With the release of The Rum Diary this Friday, Johnny Depp and Amber Heard's onscreen relationship as writer Paul Kemp and the sultry socialite Chenault has us recalling some of the greatest muses in pop culture history. Without the influence of these beautiful women upon some of the most creative and world-changing minds, many of the classics we hold dear today would have never become the subject of our nostalgia. There'd be no Annie Hall if Allen never met Keaton and no "Layla" if Clapton never came across Boyd. Continue reading to draw inspiration from The 25 Hottest Muses of All Time.

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