5. KRISTIN KREUK AS LANA LANG

Love interest: Clark Kent a.k.a. Superman
During Clark's high school days on Smallville, he only had his X-ray eyes on one girl in the locker room: Lana Lang. Yet she ultimately married, and got impregnated by, his best friend turned archenemy on the show, Lex Luthor. Understandably, for the show to last ten seasons, they needed to follow the long-running soap opera formula.