1. Jennifer Aniston (Rachel Green)

Biggest W since Friends: Aniston has co-starred in some pretty big films like Bruce Almighty, The Break-Up, and Marley and Me. We didn't particularly like them, but all three movies made over a $100 million at the box office.
Biggest L since Friends: She was just nominated for a Razzie for her role in the awful The Bounty Hunter.
Noticeable relationships: Since divorcing Brad Pitt, Aniston has had flings with John Mayer, Gerard Butler, and Vince Vaughn.
Public scandals: Brad Pitt notoriously had an affair with Angelina Jolie while he was still married to Aniston, his wife of four years. The betrayal, which still makes tabloid headlines to this day, made most people feel for Aniston. Pitt of course married Jolie, who went from hot sexpot to weird matriarch recreating Captain Planet and the Planeteers using adopted children, so Aniston looks even better now.
Complex says: The big knock on Aniston remains that she can’t carry a movie by herself; she needs the help of a major star for a blockbuster hit. Still, she regularly gets up to $8 million a picture, and, whether it's because of her acting ability or some public romance, her name is always out there. Who needs Friends anyway?