Big Brass Balls from Bioshock 2

Description: Finish the game without using Vita-chambers.
Stallion Says: "I'm a sucker for cheap jokes."
How to Get It: Of all of the achievements on this list, this is the one that may drive you mad. Vita-chambers are the game's way of incorporating checkpoints. Not using them means that you have to, y'know, not die. There's no secret sauce to doing that other than managing your health packs well and avoiding enemies as much as you can. Thankfully, this can be done on any difficulty, so feel free to go the kiddie route.