Producer: Eminem, Luis Resto, Jeff Bass
Album: Music from and Inspired by the Motion Picture 8 Mile
Label: Shady/InterscopeYou only get one shot, do not miss your chance to blow
This opportunity comes once in a lifetime, yo!

One doesn't have to be a rapper tryin' to get put on to feel those motivational words. The pressure to survive (and the pressure to be great) is captured in all its essence on "Lose Yourself," which won the Oscar for Best Original Song for the film 8 Mile and set a record for time spent sitting at the No. 1 position on Billboard's Hip-Hop Singles Charts. Eminem's cinematic debut was a breakthrough; some of the parents of kids who dragged them to theaters were exposed to his talents and some of that hate for him melted away.

The song itself benefited from the ability to connect emotionally with people (When he says, "Success is my only motherfuckin' option, failure's not," you can feel the urgency). The serene music at the start that gives way to the chunky guitar riff does for hip-hop fans what the "Theme from Rocky" does for boxing enthusiasts—gets them hyped the fuck up. "You can do anything you set your mind to," he tells us at song's end, and for that second you believe him.

Almost 10 years later, when the song was used for the high-profile Chrysler commercial, the second the instantly recognizable riffs start growling, the same emotional impact from the first time you heard the song kicks in. Eminem came up playing the underdog role and people love underdogs, probably because we're all underdogs at some time in our lives.