Producer: Ryan Leslie
Album: Cassie

Not only did this mark the start of Cassie's rapid rise to pop stardom (one she was not ready for), but it's also the moment producer Ryan Leslie became a go-to guy in the music industry. Under Cassie's coos to a guy she's ready to get busy with are shooting synths and chord progressions that, now evolved, are the types of soundbeds rappers like Fabolous ask to jump on often. “Me & U,” formerly a top 10 record on Billboard's hot 100 chart, is still her biggest record six years later. And while R. Les is still known to cut a banger or two on the reg, who knows if she'll ever make it back to '06's height.