Released: 1990
Fun Fact: Dr. Mario appears as a character in Super Smash Brothers Melee. He throws pill capsules to attack opponents.
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Dr. Mario was a lighthearted puzzle game. Players would have to use color-coded medicine pills and match them with like-colored viruses to destroy them. The color of the pills was random and so the game played out similarly to Tetris. When four or more viruses or pill pieces were aligned in a row, they would all vanish simultaneously.

In the 2-player mode, whoever emptied out their bottle full of viruses first won the round. The winner was the first player to win three games in total.