Game: Parasite Eve
What Makes Her Bad: Eve wishes to imbue all the world with mitochondrial essence...and/or immolate them.
What Makes Her Cool: That hair, those strange claws, and the ability to cause every single body in the opera house to spontaneously combust makes Eve particularly awesome.
Eve's greatest hour was no doubt in the beginning of the original Parasite Eve, which marked an iconic departure in survival horror and made the mitochondrial queen one of the most memorable villains in the PlayStation era. Floating around with her gravity-defying hair and mammoth claws, she's a sight to behold.