The 50 Best Puzzle Games of All Time

14. Dr. Mario

Year: 1990
System: NES

Leave it to Mario to save the Mushroom Kingdom from any ill that ails it, including germs. You probably know the drill here: taking their own stab at the matching tile formula, Mario has match the colors in dual or single-color pills in order to eliminate nasty bugs. To this day, it’s still a pretty challenging puzzle game. Who knew the Mario remedy worked so well?

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