Duken Nukem: Manhattan Project
Manhattan Project wasn't your typical Duke Nukem game. Instead of a gory, chauvinistic, hilarious first-person shooter, it was a gory, chauvinistic, hilarious third-person side scrolling platformer.
In it, Mech Morphix (who bears a starling resemblance to the original Duke's Dr. Proton), unleashes radioactive slime to mutate the creatures of Manhattan in a bid to take over the island. Needless to say, the pigeons get even more annoying.