System: Famicom/NES
Trivia: Super Mario Bros. was the best-selling game of all time until Wii Sports dethroned it in 2009.
Year: 1985
This is the one that started it all. And by "it," we mean the many successive years of Nintendo dominance in the industry (with a few hiccups along the way, of course). Mario became a household name, brought in billions of revenue for the Big N, and turned a generation of schoolyard freeze-taggers into couch-potato button-mashers. Rejoice, wieght-loss gurus!