System: Nintendo DS
Trivia: New Super Mario Bros. was the first original (non-remake) Mario title to feature voice acting, with the voice of Mario being none other than Charles Martinet.
Year: 2006

Seizing on the popularity of Mario Kart's DS edition, Nintendo released an all-new take on the classic platform series that was engineered specifically to take advantage of the DS' hardware. The dual screens provided both a viewing area and a utility screen to switch off stored mushrooms, enabling Mario to supersize (with the Mega Mushroom) or miniaturize (with the Mini-Mushroom) himself accordingly. Or simply to expand his mind (with the Psilocybin Mushroom). Or maybe that was just our college roommate Mario.