Game: 2005 American League Divisional Series, Game 3
It had been a lifetime since the White Sox experienced any kind of postseason success so, even up 2-0 in the '05 ALCS, there was a fear that the Pale Hose would choke away the series.
The here-we-go-again moment came in the bottom of the sixth when the Red Sox loaded the bases with nobody out. Clinging to a one-run lead, Orlando Hernandez came out of the bullpen and got Jason Varitek to foul out, Tony Graffanino to pop out, and Johnny Damon to strike out on a did-he-or-didn't-he check swing. Boston left their runners stranded, Chicago closed out the game, and won their first playoff series since 1917.