47. Shox R4
Year Introduced: 2000
Nike Shox was in development even before Air debuted, so by the time it launched in 2000 it was one of the most heavily-researched cushioning systems in sneaker history. Smartly, Nike chose to let the technology serve as its own design language with the initial launch, and the R4 runner (R for running, 4 for the number of Shox pillars) looked more like a NASA product than a Nike one. And even though heelstrike, which the Shox pillars were built to handle, is considered just about the worst thing a runner can do, the R4 still stands as a design triumph.