8. Route 10, Mobile, AL to New Orleans, LA
You'll pass by Civil War era mansions and fishing shacks on your trip from Mobile through Biloxi to New Orleans. Of course, the food, music, and culture of New Orleans is legendary, but this trip will also allow you to be a riverboat gambler in Biloxi and eat some of the best seafood you've ever had in the huge fishing town of Mobile. From the beginning of your journey, coming east over the scenic Jubilee Parkway Bridge, this will be one of the most interesting stretches of road you've ever seen.