10. Interstate 40, Los Angeles, CA to Nashville, TN
If you've been aching for a motorcycle road trip, go west young man. Though I-40 stretches all the way across the country to Nashville, the first stretch, filled with desert and punctuated by the Grand Canyon, is the route that the counterculture rebels rode in Easy Rider. The Eastern half of the trip is pretty great too; you'll pass through legendary tourist destinations like Graceland and the natural beauty of Hot Springs National Park. As far as cuisine goes, make sure you hit the Big Texas Steak Ranch in Amarillo, Texas, home to the 72-ounce Steak Challenge.